AANS/CNS SECTION
ON TUMORS

You can now view all the Tumor Section Session presentations from the 2015 CNS Annual Meeting.

 

Click here to view the presentations.

Link is accessible for CNS members only.

 

Sunday, September 27, 2015

Choice Abstracts: Spanning the Spectrum of Neurosurgery

Room 203/204/205, New Orleans Ernest N. Morial Convention Center

Moderators: Alexander Arash Khalessi, John K. Ratliff, Krystal Lynne Tomei

 

2:12 – 2:18 pm

107 ReACT: Overall Survival from a Randomized Phase II Study of Rindopepimut (CDX-110) Plus Bevacizumab in Relapsed Glioblastoma

David A. Reardon; James M. Schuster; David Dinh Tran; Karen L. Fink; Louis B. Nabors; Gordon Li, Daniela Annenelie Bota, Rimas Vincas Lukas, Annick Desjardins, Lynn Stuart Ashby, J. Paul Duic, Maciej M. Mrugala, Andrea Werner, Thomas Hawthorne, Yi He, Jennifer Green, Michael Jay Yellin, Christopher D. Turner, Thomas A. Davis, John H. Sampson

 

STRYKER NEURO-ONCOLOGY AWARD

3:00 – 3:06 pm

115 Early Versus Late Gamma Knife Radiosurgery Following Transsphenoidal Resection for Nonfunctioning Pituitary Macroadenomas: A Matched Cohort Study

Isaac Jonathan Pomeraniec, Robert Dallapiazza, Zhiyuan Xu, John Jane, Jr., Jason P. Sheehan

 

NATIONAL BRAIN TUMOR SOCIETY MAHALEY CLINICAL RESEARCH AWARD

3:48 – 3:54 pm

123 Quantitative Volumetric MR Perfusion Identifies a Distinct Vasculogenic Molecular Subtype of Human Glioblastoma Associated with Worse Clinical Outcomes

Achal Singh Achrol, Tiffany Liu, Lex A. Mitchell, Joshua J. Loya, Erick M. Westbroek, Scott Rodriguez, Abdullah Feroze, Steven D. Chang, Daniel Rubin, Griffith R. Harsh

 

Monday, September 28, 2015

Section on Tumors Oral Presentations

Room 206, New Orleans Ernest N. Morial Convention Center

Moderators: Bob S. Carter, Allen Waziri

 

SYNTHES SKULL BASE SURGERY AWARD

7:00 – 7:09 am

134 Comparison of Extent of Tumor Resection and Endocrine Outcomes for Nonfunctioning Pituitary Adenomas of a Less Experienced Surgeon Using a Fully Endoscopic Transsphenoidal Surgery Technique to a Very Experienced Surgeon Using a Microscopic Transsphen

Hasan Zaidi, Michael Bohl, Al-Wala Awad, Kristina Chapple, Laura Knecht, Heidi Jahnke, William L. White, Andrew S. Little

 

INTEGRA FOUNDATION AWARD

7:09 – 7:18 am

135 Imaging Patterns Predict Patient Survival and Molecular Subtype in Glioblastoma Using Machine Learning Techniques

Jared M. Pisapia, Luke Macyszyn, Hamed Akbari, Xiao Da, V. Pigrish, Mark Andrew Attiah, Yingtao Bi, Sharmistha Pal, Ramana Davaluri, Laura Roccograndi, Nadia Dahmane, George Biros, Ronald L. Wolf, Michel Bilello, Donald M. O'Rourke, Christos Davatzikos

 

BRAINLAB NEUROSURGERY AWARD

7:18 – 7:27 am

136 Complete Resection of Contrast Enhancing Tumor Volume is Associated with Improved Survival in Recurrent Glioblastoma – Results from the DIRECTOR Trial

Bogdana Suchorska, Michael Weller, Ghazaleh Tabatabai, Christian Senft, Peter Hau, Michael Sabel, Ulrich Herrlinger, Ralf Ketter, Uwe Schlegel, Christine Marosi, Guido Reifenberger, Wolfgang Wick, Joerg-Christian Tonn, Hans-Georg Wirsching

 

AMERICAN BRAIN TUMOR ASSOCIATION YOUNG INVESTIGATOR AWARD

7:27 – 7:36 am

137 Somatostatin Receptor Expression on VHL-associated Hemangioblastomas Offers Novel Therapeutic Target

Michael Feldman, Martin G. Piazza, Nancy A. Edwards, Abhik Ray-Chaudhury, Dragan Maric, Marsha J. Merrill, Zhengping Zhuang, Prashant Chittiboina

 

JOURNAL OF NEURO-ONCOLOGY AWARD

7:36 – 7:45 am

138 Diffusion MRI ADC Mapping of Glioblastoma Edema/Tumor Invasion and Associated Gene Signatures

Pascal O. Zinn, Massumeh Hatami, Rivka R. Colen

 

PREUSS AWARD

7:45 – 7:54 am

139 Human Ether-a-Go-Go-Related-1 Gene (hERG) K+ Channel as a Prognostic Marker and Therapeutic Target for Glioblastoma

John S. Kuo, Kelli Briana Pointer, Paul A. Clark, Gail Robertson

 

COLUMBIA SOFTBALL CHARITY AWARD

7:54 – 8:03 am

140 A High-throughput in Vitro Drug Screen in a Genetically Engineered Mouse Model of Diffuse Intrinsic Pontine Glioma Identifies BMS-754807 as a Promising Therapeutic Agent

Kyle Gregory Halvorson, Kelly L. Barton, Kristin Schroeder, Katherine Misuraca, Christine Hoeman, Alex Chung, Donna Crabtree, Francisco Cordero, Raj Singh, Ivan Spasojevic, Noah Berlow, Ranadip Pal, Oren Becher

 

8:03 – 8:12 am

141 Pre-operative Brain Mapping in Neuro-oncology with Graph Theory Analysis of the Functional Connectome

Michael Hart, Stephen J. Price, John Suckling

 

8:12 – 8:21 am

142 Stereotactic Radiosurgery for Medically and Surgically Refractory Acromegaly:  Long-Term Rates of Remission and Hypopituitarism

Jason P. Sheehan, Mary Lee Vance, Zhiyuan Xu, Chun Po Yen, David Schlesinger, Blair Dodson, Cheng-Chia Lee

 

8:21 – 8:30 am

143 The Combination of anti-TIM-3 and anti-PD-1 Checkpoint Inhibitors with Focused Radiation Resulted in a Synergistic Anti-Tumor Immune Response in a Preclinical Glioma Model

Jennifer E. Kim, Mira A. Patel, Antonella Mangraviti, Esteban Velarde, Debebe Theodros, Dimitris Mathios, Christopher Mitchell Jackson, Betty Tyler, Xiaobu Ye, Henry Brem, Drew Pardoll, Michael Lim

 

Tuesday, September 29, 2015

4:30 - 5:45 pm

Section on Tumors Neurosurgical Forum

Exhibit Hall B1/B2/C

Moderators: Chetan Bettegowda, Orin Bloch

 

785  Predictors of Unfavorable Outcomes Following Craniotomy for Excision of Vestibular Schwannoma and the Effect of Hospital Case Volume on Outcomes: A National Inpatient Sample (2005-2011) Analysis of 16,680 Patients Across 300 United States Hospitals

Piyush Kalakoti, Symeon Missios, Osama Ahmed, Jerry McLarty, Maura Cosetti, Anil Nanda

 

786  Single-Cell Microfluidic Genetic Profiling Reveals Two Distinct Subsets of Brain Tumor-Initiating Cancer Stem Cells Co-Existing in Human Glioblastoma Before and After Therapeutic Intervention

Achal Singh Achrol, Robert Rennert, Michael Januszyk, Tiffany Liu, Suzana Kahn, Debashis Sahoo, Steven D. Chang, Gary K. Steinberg, Samuel Henry Cheshier, Geoffrey Gurtner, Griffith R. Harsh

 

787  Cumulative Intracranial Tumor Volume Thresholds for Predicting Survival After SRS Varies By Tumor Histology

Logan P. Marcus, Brandon A. McCutcheon, Jona A. Hattangadi, David D. Gonda, John F. Alksne, Bob S. Carter, Masaaki Yamamoto, Clark C. Chen

 

789  Neuroanatomic-Genomic Mapping Reveals Distinct Brain Regions of Tumor Formation Influencing Molecular Subtypes of Human Glioblastoma

Achal Singh Achrol, Tiffany Liu, Debashis Sahoo, Hannes Vogel, Lex A. Mitchell, Robert Tibshirani, Erick M. Westbroek, Joshua J. Loya, Scott Rodriguez, Abdullah Feroze, Steven D. Chang, Gary K. Steinberg, Daniel Rubin, Griffith R. Harsh

 

790  Anti-GITR Antibody and Stereotactic Radiation Induces Immune-mediated Prolongation of Survival in Murine Intracranial Glioma

Mira A. Patel, Jennifer E. Kim, Debebe Theodros, Christopher Mitchell Jackson, Esteban B.S. Velarde, Betty Tyler, Mark Selby, Xiaobu Ye, Henry Brem, Drew Pardoll, Michael Lim

 

791  Multicenter Review of the Impact of Laser Ablation on Overall Survival and Progression Free Survival of Patients with Newly Diagnosed Glioblastoma

Alireza M. Mohammadi, Veronica Chiang, Thomas L. Beaumont, Bryan S. Lee, Volodymyr Statsevych, Gene H. Barnett, Eric C. Leuthardt

 

792  Patterns of Recurrence and Toxicity for Pre-operative versus Post-operative Stereotactic Radiosurgery (SRS) for Resected Brain Metastases: A Multi-Institutional Analysis

Roshan S Prabhu, Kirtesh R. Patel, Stuart H. Burri, Chao Zhang, Zhengjia Chen, Ian R. Crocker, Robert W. Fraser, III, Scott Daniel Wait, Shravan Kandula, Costas G. Hadjipanayis, Walter Curran, Hui Kuo G Shu, Anthony L. Asher

 

793  Association Between DNA Damage and Glioblastoma Distance to the Subventricular Zone: A Correlation of Molecular Physiology and Radiographic Findings

Tyler Steed, Jeffrey M. Treiber, Kunal S. Patel, H. Billur Engin, Hannah Carter, Anders Dale, Bob Carter, Clark C. Chen

 

794  Polymeric Nanoparticles for Non-Viral Gene Therapy Extend Brain Tumor Survival In Vivo

Antonella Mangraviti, Stephany Tzeng, Kristen Kozielski, Yuan Wang, Yike Jin, David Gullotti, Mariangela Pedone, Nitsa Buaron, Ann Liu, Sarah Hansen, Fausto J. Rodriguez, Guo-Dong Gao, Francesco DiMeco, Henry Brem, Alessandro Olivi, Betty Tyler, Jordan Green

 

795  Characterization of Blood-derived Microparticles from Glioblastoma (GBM) Patients Following Oral Loading with 5-ALA

Costas G. Hadjipanayis, Walter Stummer, Alan M. Ezrin

 

797  Isocitrate Dehydrogenase (IDH) Mutation and Methyl-Guanine Methyl Transferase (MGMT) Promoter Methylation Status as Independent Glioblastoma Biomarkers

Clark C. Chen, Tao Jiang, CGGA Consortium

 

798  The Role of Postoperative Adjuvant Radiotherapy for the Treatment of Intracranial Atypical (WHO Grade 2) Meningiomas: A Systematic Review and Meta-analysis of 1001 Patients

Jigar S. Gandhi, Zachary S. Mendelson, Jean Anderson Eloy, James K. Liu

 

799  Morphometric Analysis of the Middle Clinoid Process Using Maxillofacial CT Scans

Christopher Miller, Roukoz B. Chamoun

 

800  Activatable Fluorescent Nanoprobes for Rapid and Specific Identification of Central Nervous System Lymphoma

Joseph F. Georges, Xiaowei Liu, Michael Anthony Mooney, Jennifer M. Eschbacher, Zubair Ahammad, Burt G. Feuerstein, Robert F. Spetzler, Mark C. Preul, Kailash Narayan, Hao Yan, Peter Nakaji

 

801  Hospital Surgical Volume as a Source of Variation in Failure to Rescue and Inpatient Mortality Following Craniotomy for Resection of Intracranial Neoplasms

Hani Rimlawi Malone, Michael Brendan Cloney, Jingyan Yang, Alfred Neugut, Jeffrey N. Bruce

 

802  Neurocognitive Outcome in Patients with Nonfunctional Pituitary Tumor Treated with Transsphenoidal Surgery: Preliminary Report

Kuo-Wei Chen, Shih-Hung Yang, Ching-Ju Yang

 

803  Glioma Survival Prediction Study: Identification of Prognostic Factors and Development of an Optimized Mixed Model Algorithm for Prediction of Glioma Survival Time

Hoon Choi, Frank Middleton, Manu K. Arul, Satish Krishnamurthy, David A. Carter, Walter A. Hall, Lawrence S. Chin

 

804  Glioblastoma Stem Cells Demonstrate Abnormal Mitochondria and a Dependence on Glucose for Cell Proliferation and Survival

Sumedh Subodh Shah, Gregor Rodriguez, Zachary Charles Gersey, Winston Walters, Andrew L. Middleton, Amade Bregy, Ricardo Jorge Komotar, Jeffrey S. Prince, Regina Graham

 

805  Knockout of the LKB1 Gene Causes Transformation and Selective Re-expression of Stem Cell Markers in Astrocytes

Herbert H. Engelhard, David Braun, Douglas L. Feinstein

 

806  Consolidating and Functionalizing a Decade of Work – A Retrospective Approach to Classification of Malignant Gliomas Based Solely on Gene Expression Profiling

Haya Sarras, Megan Wu, Angela Celebre, Daniele Merico, Jason Karamchandani, Sunit Das

 

807  A Chromatin Mediated Quiescent State Underlies Resistance to Targeted Therapy in Glioblastoma

Anoop Patel, Brian Liau, Bradley Bernstein

 

808  Survival Impact of Antidepressants in Patients with Glioblastoma

Josue Moises Avecillas-Chasin, Gustavo Gomez, Pedro Perez Segura, Javier Saceda, Subhi Issa, Juan A. Barcia

 

809  Chromosomal Aberrations in Atypical and Anaplastic Meningiomas: Prognostic Implications

Dwarakanath Srinivas, Nishanth Sadashiva, Vani Santosh, Sampath Somanna

 

810  Nasoseptal Flap Necrosis: A Rare Complication of Endoscopic Endonasal Surgery

Joseph D. Chabot, Chirag Patel, Ali Kooshkabadi, Nathan Zwagerman, Eric Wang, Carl Snyderman, Paul A. Gardner, Juan Carlos Fernandez-Miranda

 

812  Perioperative Hyponatremia in Over 1000 Glioblastoma Patients: Associated Risk Factors and Morbidities

Arman Jahangiri, Rebecca M. Chen, Jeffery Wagner, Aaron Chin, Nicholas Butowski, Jennifer L. Clarke, Michael Prados, Susan Chang, Andrew T. Parsa, Michael William McDermott, Mitchel S. Berger, Manish Kumar Aghi

 

813  Endoscopic Endonasal Approach to the Petrous Apex: Indications and Outcomes

Robert Austin Miller, Paul A. Gardner, Juan Carlos Fernandez-Miranda, Maria Koutourousiou, Joseph D. Chabot, Carl Snyderman

 

814  Protein Expression of Angiogenesis Markers in the Prognosis of Human Gliomas

Jason Harrison, Hope T. Richard, Christine Fuller, William C. Broaddus

 

815  Strong Cytotoxic Reaction in Malignant Glioma Tissue After Locoregional Cisplatin Administation by Micodialysis

Pedram Tabatabaei Shafiei, Mikael Johansson, Per Bergström, Thomas Asklund, Tommy A. Bergenheim

 

817  Giant Macroadenomas: Redefining Size Criteria Based on Surgical Outcome Data

Seunggu J. Han, John David Rolston, Sandeep Kunwar, Lewis Blevins, Manish Kumar Aghi

 

818  Prospective Comparison of Sinonasal Outcomes after Microscopic Sublabial and Endoscopic Endonasal Transssphenoidal Surgery for Nonfunctioning Pituitary Adenomas

Daniel Raper, Carrie Pledger, Spencer Payne, John Jane, Jr

 

819  Residual Tumor Volume Predicts Treatment Failure in Patients Undergoing Adjuvant Radiotherapy for Subtotally Resected Atypical Meningioma

Douglas Hardesty, Peter Nakaji, Nader Sanai

 

820  The Role of Isocitrate Dehydrogenase 1 and 2 Mutation in Glioblastoma Clinical Prognosis

Michael Karsy, Jayson Andreau Neil, Jian Guan, Fred Moy, Randy L. Jensen

 

821  Perioperative Seizure in Patients with Glioma is Associated with Increased Hospital Length of Stay, Readmission, and Overall Healthcare Burden

Michael C. Dewan, Gabrielle A. White-Dzuro, Philip Ryan Brinson, Reid C. Thompson, Lola Blackwell Chambless

 

822  Brain and Spinal Cord Glioma Microenvironment Modulates Tumor Phenotype

Jason A. Ellis, Michael Castelli, Marcela Assanah, Jeffrey N. Bruce, Peter D. Canoll, Alfred T. Ogden

 

824  Natural History of Hemangioblastoma-associated Cysts in Von Hippel-Lindau Disease (VHL) Patients

Kristin Huntoon, Edward H. Oldfield, Russell R. Lonser

 

825  Craniotomy for Recurrent Glioblastoma: Is it Justified? A Single Centre Experience with Outcomes Over 10 Years and a Review of the Literature

Soumya Mukherjee

 

826  Gene Expression Analysis of Pseudoprogression and True Progression in Newly Diagnosed GBM

Adam M. Robin, Laila Poisson, Aditya Raghunathan, Lisa Scarpace, Charlotte Burmeister, Tobias Walbert, Denise Leung, Tom Mikkelsen, Ian Yu Lee

 

827  Risk Factors for Postoperative Seizure in over 1000 Glioblastoma Patients

Arman Jahangiri, Rebecca M. Chen, Jeffery Wagner, Aaron Chin, Nicholas Butowski, Jennifer L. Clarke, Michael Prados, Susan Chang, Andrew T. Parsa, Michael William McDermott, Mitchel S. Berger, Manish Kumar Aghi

 

828  Stereotactic Radiosurgery, a Disruptive Technology in the Management of Brain Metastases

Edward A. Monaco III, Nicolas K. Khattar, Greg N. Bowden, Yu-Fang Chang, Ajay Niranjan, L. Dade Lunsford

 

829  Neurofibromatosis and Acoustic Neuroma Resection: A Nationwide Inpatient Sample Analysis

Hormuzdiyar H. Dasenbrock, Wenya Linda Bi, Donnovan Guitierres, Ossama Al-Mefty, Ian F. Dunn

 

830  Tumor Inoculation with E.aerogenes Results in Prolonged Survival in a Rat GBM Model

J. Paul Muizelaar, Rudolph J. Schrot

 

831  Meningiomas Invading the Superior Sagittal Sinus: Surgical Experience in 310 Cases at an Italian Tertiary Referral Center

Cecilia Casali, Federico G. Legnani, Carla Richetta, Alessandro Moiraghi, Ignazio G. Vetrano, Francesco Prada, Alessandro Perin, Andrea Saladino, Luca Mattei, Antonella Mangraviti, Francesco DiMeco

 

832  Adult Neural Stem Cells Are Irreplaceable After Quiescent Stem Cell Targeted Therapy

Terry C. Burns, Dominic Rodriguez, Sunny Kumar, Kambiz Ansari, Theo D. Palmer

 

833  3D Laser Scanning of Bones: A Novel Method for Quantitative Comparison of Skull Base Approaches

Manjul Tripathi, Ashish Suri, Rama C. Deo, Natesan Damodaran, Vinkle Srivastav, Britty Baby, Prem Kalra, Subhashis Banerjee, Tara S. Roy, Sanjeev Lalwani

 

835  Outcomes in Patients with Vestibular Schwanoma after Subtotal Resection and Adjuvant Radiosurgery

Hesham Radwan, Mark B. Eisenberg, Jonathan P.S. Knisely, Maged Ghaly, Michael Schulder

 

836  Radiological MRI Features of Glioblastoma Multiform and its Molecular Subtype - A Correlation with Prognosis

Jing Zhau, Ahmad Taha, Michael Reddy, Janice A. Royds, Noelyn Hung, Tania Slatter, Kirst Stenar, James Fulton, H. Morrin

 

837  30-Day Complications in the Surgical Management of Vestibular Schwannomas: Population Benchmarks and Predictors using Prospectively Collected NSQIP Data

Ali A. Alattar, Brandon A. McCutcheon, Logan Marcus, Tyler Scott Cole, Bob Carter, Clark C. Chen

 

838  Tumor Size at Diagnosis Does not Impact Normalization of Pituitary Function After Transsphenoidal Surgery for Pituitary Adenomas

Tristan Michael Stani, Chris G. Yedinak, Shirley McCartney, Justin Schultz Cetas, Aclan Dogan, Maria Fleseriu

 

839  Antitumor Activity Following Adoptive Immunotherapy with an Allogeneic Steroid-Resistant IL-13-Zetakine Expressing CD8 T-Cells in Subjects with Recurrent Glioblastoma

Behnam Badie, Jana Portnow, Julie Ressler, Massimo D'Apuzzo, Dale Ando, Andreas Reik, Philip Gregory, Winson Tang, Michael Jensen, Stephen Forman, Christine Brown